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The full benefit of this non-invasive procedure appears in four to six months

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dopamine striatal brain regions (positive symptoms of schizophrenia as an excess of dopaminergic neurotransmission)), and prefrontal brain regions (negative symptoms and cognitive deficits linked to dopaminergic hypofunction) [195,217]

"Further, while we acknowledge the corrective and preventive actions that your site has taken or plans to take, your written response is inadequate because it does not provide sufficient details about how you, as a clinical investigator, will ensure adequate oversight of the study procedures (for example, adherence to eligibility requirements)