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Another study suggested that the proportion of alginate and pectin encapsulating FA also affects the pharmacokinetic properties, or the bioavailability, with 100% alginate and 50% alginate50% pectin nanoparticles being suitable for delivery of FA to the duodenum for absorption via the proton-coupled folate transporter (PCFT), and 100% alginate being suitable for the delivery to the terminal ileum via the reduced folate carrier (RFC1) (Figure 2) [70]