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FBW7 has been shown to regulate lipid peroxidation and enhance ferroptosis in pancreatic cancer and to inhibit stearoyal-CoA desaturase (SCD1) activity [57]

doi: 10.1016/j.dnarep.2019.102701 122 WenQLiuJKangRZhouBTangD

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Depriving tumours of extracellular glutathione or inhibiting its breakdown is potentially a viable therapeutic strategy for cancer patients, the authors state

doi: 10.1002/pro.3119

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