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Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skin melanoma in vitro

Since the data used were all from public databases, patient consent or ethics committee approval were not required

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10.1158/1541-7786.MCR-19-0691 Mol

For the two samples, the severity of the subcutaneous tissue necrosis, inflammatory cell infiltration and haemorrhage distribution was assessed by a trained toxicopathologist using a light microscope and scored on a numerical scale, where code 1 reflects no abnormality and code 3 reflects mild severity: 1 , no abnormality 2, minimal severity 3, mild severity Table 22 Severity scores 24 hours post subcutaneous injections of subcutaneous tissue necrosis, inflammatory cell infiltration and haemorrhage distribution for co-formulation vehicles containing three types of tonicity agents Concluding Remarks The data presented in table 22 show that, overall, sorbitol was the tonicity agent that resulted in the least severe necrosis, inflammatory cell infiltration and haemorrhage