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Endocrinology (2022) 164(2):bqac210
JAMA Netw Open 3: e2025109
This change may also be reflected in visible signs such as reduced skin vitality and uneven tone
Heme degradation and oxidative stress in murine models for hemoglobinopathies: thalassemia, sickle cell disease and hemoglobin C disease
mtDNA damage may be more sensitive to disruptions in the DDR process compared to nuclear DNA, as mtDNA is located near the electron transport chain (ETC) and lacks the protective histone shielding present [46]
