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In contrast, LLS could be due to somatic defects in genes related to tumor onset and progression or due to biallelic alterations in MMR genes outside MLH1 promoter methylation [2,3,58], thus having a sporadic origin

ROS, including superoxide (O 2 -) and hydrogen peroxide (H 2 O 2 ), play a central role in host defense by killing microbes in phagocytic cells

longer-term harms in the real world are detectable only from pharmacoepidemiologic studies

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local anesthetics