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Moreover, this may be a fully controlled response providing, for instance, in the counteraction of tumor-induced cachexia, the inhibition of catabolic pathways (IL-6, TNF-alpha) balanced with the stimulation of anabolic pathways (FoxO3a, p-AKT, p-mTOR, and P-GSK-3) [6]

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Intermittent 10-20 day cycles are standard

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