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Despite that, in one study of rats and ligaments, good effects were observed when it was provided orally (1)

This complex includes the nucleus tractus solitarius (NTS), the area postrema (AP), and the dorsal motor nucleus of the vagus nerve (DMV)

Biochemistry 41:22542263 Bae S, Oh K, Kim H, Kim Y, Kim HR, Hwang YI, Lee DS, Kang JS, Lee WJ (2013) The effect of alloferon on the enhancement of NK cell cytotoxicity against cancer via the up-regulation of perforin/granzyme B secretion

Finally, because the injection is done inside the spinal canal, the spinal nerves can be damaged by the needle itself

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doi: 10.3109/17453679909000958