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Key concepts in bridging therapies: Biologic modifiers are available to treat specific diseases Outcome of long-term therapy needs to be studied Optimising patient status prior to HSCT with such agents is useful to improve outcome Conditioning Historically, conditioning therapy prior to HSCT for patients with IEI was based on the alkylating agents busulfan and cyclophosphamide

Yet BPC-157 alone may not fully solve: Long-term tissue organization: You can build tissue quickly without building it well

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Incorporating analogous mitochondria directed GSH-sensing reporters into nanoplatforms would allow simultaneous readout and modulation of intramitochondrial redox status, enabling closed-loop theranostic schemes i.e

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Lawson LJ, Perry VH, Dri P, Gordon S (1990) Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain