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"The use of naltrexone in low doses beyond the approved indication of opioid addiction"
HDL-induced NO underlies many of HDLs beneficial properties to endothelial cells, including HDL-induced vasodilation, tightening of cell-to-cell junctions and increased barrier function, differentiation of endothelial progenitor cells, cell survival and proliferation, cell migration, inhibition of apoptosis, and suppression of adhesion molecule expression
The mechanisms remain unclear, potentially involving rapid weight loss affecting hormones or direct effects, but further research is needed
These may arise indirectly from rapid weight loss-induced metabolic shifts, including nutrient and electrolyte depletion (e.g., magnesium, potassium, B-vitamins, iron), mitochondrial energy stress, and release of stored fat-soluble toxins (environmental chemicals, pesticides) into circulation during adipose tissue breakdown
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W., da Silva, L., Maciel, G., Huguenin, A
