l carnitine atherosclerosis Mammalian-Microbial Cometabolism of L-Carnitine in the Context of TMAO and Heart Health: What

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We further identified type I interferon (IFN-I) signaling as a key upstream regulator that induces Chac2 expression and drives metabolic reprogramming

It increases the expression of the oxidative/inflammatory gene NF-B as well as the expression of two NF-B inhibitors, TLE and ILBP

Detailed analysis has been carried out including their chromosomal distribution, genomic architecture and localization

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