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This microenvironment is characterized by the physiologic presence of bacterial constituents such as endotoxin and by the local release of immunosuppressive mediators such as interleukin-10, prostaglandin E 2 , and transforming growth factor-

[PubMed] [Google Scholar] [194].Frost P, Weinstein GD, Gomez EC, Methacycline and demeclocycline in relation to sunlight, JAMA 216 (2) (1971) 326329

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