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Description
Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling

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By modulating key enzymes and signaling pathways, ROS significantly affects core processes such as glycolysis [168], gluconeogenesis [169], and the insulin signaling pathway [170]

doi: 10.1038/ncomms13125 [DOI] [PMC free article] [PubMed] [Google Scholar] 11

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