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Interestingly, Luo M et al

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IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts

390 Although some in vitro studies have suggested that opiates diminish endogenous interferon alfa production, 391 there are several studies of persons taking methadone that suggest that the drug does not significantly reduce the likelihood of an SVR, nor does it alter the dosing of interferon alfa or ribavirin

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