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In addition, there is a U-shaped association between selenium exposure and some diseases, such as type 2 diabetes and fractures [117]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 79

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Activation of NF-k antagonizes programmed cell death induced by TNFR1, and GSH depletion has been shown to down-regulate TNF-induced NF-k activation and sensitize to apoptotic cell death [123]

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In contrast, inducing autophagy with rapamycin (100 nM) attenuated SIPS

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