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Among the myriad of AD-related brain alterations, damage to glutamatergic neurons and circuits stands out and has been linked to glutamate toxicity, but until very recently, there was little direct evidence for elevated brain glutamate levels in the affected persons brains (Singh et al., 2021

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Furthermore, we demonstrated that RSL3 treatment impairs the phosphorylation of other downstream mTOR-related proteins, such as S6 and 4E-BP-1

doi: 10.1097/01.jcp.0000264976.86990.00