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After discussing the various therapeutic options, the physician recommends the initiation of therapy with oral methotrexate plus a concomitant folic acid supplement
Khalil MI et al

Of note, patients with advanced cancers are likely to carry distal metastases, which are the primary cause of cancer-related mortality

Transpl Infect Dis (2010) 12:2209

This allows particles into the bloodstream that are not supposed to be there, such as those from foods or medications, triggering the inflammation response of the NEM

No amount of careful storage afterward can undo shake damage
