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doi: 10.1159/000488913

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What they found: NR is rapidly absorbed orally , peak at 30 minutes NR is converted to NAD+ in multiple tissues , liver, muscle, blood Plasma NAD+ rises 2 to 8 after a single dose Optimal dosing regimens: 100 to 1000 mg No accumulation of toxic metabolites Why it matters: This is the reference pharmacokinetic publication for NR and NMN

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141,143148 Several lines of evidence have indicated that extracellular loops (EL1 and EL2) of claudins are important for both trans - and cis -claudinclaudin interactions