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The role of SAM consists in positive allosteric feedback activation: SAM production in transmethylation path enhances the whole process
IGF-1 contributes to lung re-epithelialization, acting as an anti-apoptotic factor, and stimulates the in vitro synthesis of collagen by fibroblasts, thus leading to the production of extracellular matrix [83, 90, 91]

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The role of vitamin E in cystic fibrosis disease remains a subject of intense debate within current research