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The EHT extract of claim 1, having a weight ratio of at least about 100: 1 late eluting tryptamides:early eluting tryptamides

Liu Z, Zhang W, Zhang J, et al

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doi: 10.1093/biolre/ioy019 99 KuokkanenSChenBOjalvoLBenardLSantoroNPollardJW

Ricciolini, M.E

Cobicistat exposures at these doses were approximately 7 (male) and 16 (females) times, respectively, the human systemic exposure at the therapeutic daily dose