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The baseline muscle biopsy of patient 5 demonstrated strong immune cell infiltration, pathologic complement deposition, increased MHC-I expression and extensive muscle fiber necrosis
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developed polymerlipid hybrid mRNALNPs, composed of cationic lipid G0C14, polymer hyaluronic acid targeting CD44, and DSPEPEGMannose targeting glucose transporters [61]
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In particular, we were unable to show a decrease in creatine, despite using the same design and MRS methodology, including the use of the same scanner and MRS sequences
