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However, the co-expression of all four Rspondins predominantly in the DP is likely to complicate the analysis of a single ablation as a result of functional redundancy or accumulative effects that are proportional to the levels of each Rspondin

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References Novo Nordisk presents phase 3 data for next-generation amylin cagrilintide, leading to advancement into dedicated clinical Programme, 16 September 2025, Novo Nordisk, DAscanio AM, Mullally JA, Frishman WH