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Cancer cells must maintain metabolic homeostasis in a wide range of conditions, including harsh microenvironments in which cancer cells must continue to meet the high bio-energetic demand in order to undergo replication 1

The knowledge gained from in vitro , preclinical, and animal studies has encouraged a variety of clinical trials investigating the role of dietary choline supplementation in disease progression ( Table 1 ), as well as the association between circulating choline-containing metabolites and disease prognosis or clinical symptoms ( Table 2 )

Es ist ratsam, die Dosis zu berwachen, um mgliche Unannehmlichkeiten zu minimieren

Notably, there were no significant differences in adverse effects between the NR and placebo groups

Can J Surg

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