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In cutaneous melanoma, melphalan treatment was associated with enhanced expression of the pro-inflammatory cytokines: IL-1, IL-8, and IL-6 and was found to induce apoptosis through ER stress and reactive oxygen species [198]

[DOI] [PMC free article] [PubMed] 61.Ayman AH, Anas AO, Yasser AA, Masad AM, Abdullah AS, Mazen A, et al

doi: 10.3748/wjg.v17.i39.4414
For example, the treatment with acetyl-l-carnitine induced haeme oxygenase enzyme in rat astrocytes in a dose- and time-dependent fashion, heat shock protein 60 upregulation, and increased expression of the nuclear factor erythroid 2-related factor 2 transcription factor, a master regulator of antioxidant proteins [18]

doi:10.1164/rccm.200712-1809OC Turnbull F, Blood Pressure Lowering Treatment Trialists C

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