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One physiologic characteristic that may hold potential as a therapeutic target is thermoregulatory dysregulation 12 , which is among the most widely reported circadian biological abnormalities in affective disorders, including MDD

The dose of 150 nmol/kg sCT was chosen to compare the effect of sCT and cagrilintide in vivo as this dose of sCT shows the same pharmacokinetic response as the 3 nmol/kg of cagrilintide

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This intermediate genotype may be associated with moderately altered activity-dependent release of BDNF compared with the general population