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On these bases and given the relevance of endogenous opioid system in pain management, this review examines the beneficial effects of both traditional and novel compounds targeting opioid receptors, aiming to enhance understanding in this field and thus improving the chronic pain treatment

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These include the triple receptor drug retatrutide (targets GLP-1, GIP and glucagon), cotadutide, mazdutide, and servodutide (all 3 are combined GLP-1 and glucagon target), and many others