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ROS ROS are signalling molecules composed of oxygen-containing reactive entities such as the superoxide anion (O 2 ), singlet oxygen ( 1 O 2 ), the hydroxyl radical (OH) and hydrogen peroxide (H 2 O 2 ), and primarily originate from electron leakage in the mitochondrial electron transport chain [10]

Yang X, Wu LL, Chura LR, Liang X, Lane M, Norman RJ, et al

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Predominantly, these trials highlighted gastrointestinal adverse events as the most common, including nausea, vomiting, diarrhea, and decreased appetite

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