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Separately, ROS-mediated activation of c-JUN also accelerated wound healing in diabetic rats through increases in angiogenesis and re-epithelialisation 123 , whilst NOX-produced H 2 O 2 -activation of the JNK pathway increased epithelial cell proliferation in adult zebrafish tailfin healing 19

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Mechanistic Studies Subsequent research has explored the mechanisms by which NNMT regulates metabolism, with studies demonstrating that NNMT activity reduces cellular NAD+ availability, affects SAM-dependent methylation reactions, modulates sirtuin activity, and influences adipocyte differentiation and function

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