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Intramuscular injections and sublingual lozenges are superior to oral tablets for GLP-1 users because they bypass the reduced gastric absorption caused by semaglutide

SURMOUNT-MAINTAIN (Horn 2026, 112 weeks): continued top dose -21.9% vs 5 mg step-down -16.6% vs placebo -9.9%, rescue therapy 8/25/67%: Aronne JAMA 2024

BMJ open 10 (8), e033687

"Assessment report: Comirnaty" (PDF)

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