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Blood 111:402410

Zhang M, Zhang XH, He XM, Chen LX, Zhang YK (2012) A self-assembled polydopamine film on the surface of magnetic nanoparticles for specific capture of protein

Husemann, J., Loike, J

3.1.4 Nrf2 pathway During IPF pathogenesis, persistent oxidative damage contributes to epithelial injury, fibroblast activation, and ECM deposition (Hybertson et al., 2011), while the Nrf2 signaling pathway plays a crucial role in mitigating oxidative stress

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Besides lysosomal cholesterol accumulation, mitochondrial cholesterol loading has been shown to sensitize to TNF/Fas-induced steatohepatitis due to mGSH depletion (Mari et al., 2006), and hence it is conceivable that the intracellular cholesterol trafficking to different compartments (i.e., lysosomes and mitochondria) determines APAP hepatotoxicity by different mechanisms including oxidative stress/mitochondrial dysfunction and impaired mitophagy