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5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the cytosolic enzyme that methylates nicotinamide to 1-methylnicotinamide (1-MNA) using S-adenosyl-L-methionine (SAM) as the methyl donor

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Journal of Endocrinology and Metabolism, 3(12), 715

This mechanism naturally limits absorption when B12 is consumed in large quantities, with excess amounts typically eliminated through the kidneys without causing harm

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