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The answer challenges a common assumption: combining two peptides isn't inherently problematic if their mechanisms of action don't compete for the same receptors or pathways

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The human tripeptide GHK was discovered in 1973 as an activity in human albumin that caused old human liver tissue to synthesize proteins like younger tissue

Dynein motors facilitate the retrograde transport of cargo in axons and transport in both directions (anterograde and retrograde) in dendrites [83], while kinesins facilitate anterograde trafficking

Nature 458 , 11311135 (2009)

The authors sincerely thank Professor Graham Rook (University College London, United Kingdom) for discussions on his Old Friends Hypothesis and critical reading of the manuscript, and Professor Hanna Kmita (Adam Mickiewicz University, Poznan, Poland) for a critical reading of the manuscript and helpful suggestions for its improvement