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Chronic sleep deprivation and stress elevate cortisol and pro-oxidant cytokines, worsening insulin resistance and endothelial dysfunction (Lee et al., 2020)

Modern clinical protocols are increasingly considering evidence-based phytotherapeutics such as Iberogast , Triphala , and Licorice root extracts as adjunct therapies, particularly where long-term drug use poses risks of adverse effects

Sclafani F, Kim TY, Cunningham D, Kim TW, Tabernero J, Schmoll HJ, et al

Conversely, when GPX8 is silenced, the histamine-induced release of Ca 2+ from the endoplasmic reticulum to mitochondria and cytoplasm is increased (Yoboue et al., 2017)

Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs