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One of the prevalent and reliable parameters for determining antioxidant defense ability is GSH levels

Gronwald JW, Plaisance KL 1998 Isolation and characterization of glutathione S-transferase isoenzymes from sorghum

The clinical trials of other glutamine antimetabolites, glutaminase inhibitors, glutamine uptake inhibitors have not been reported

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The IVR domain contains a 3-box motif in its proximal part, which provides an additional CUL3 interaction site [116], and two critical cysteine residues, Cysteine273 (C273) and Cysteine288 (C288), that are important for the repression of NRF2 activity [126]