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Glutathione can reduce tyrosinase activity in different ways: - Direct inactivation of tyrosinase (the key enzyme of melanogenesis) by binding the copper-containing active site of the enzyme

No, while it may indirectly help with weight reduction by improving metabolism and detoxifying, it should be used with a healthy diet and regular exercise

Abbreviation: NAC, N-acetylcysteine

The presence of the Cu metabolism gene MURR1 also known as COMM domain-containing protein 1 (COMMD1) plays a catalytic roll in this process (30,31)

Plasmids Plasmids used in this study are listed in Supplemental Table S2

Oxidative stress refers to a state where there is an elevated production of reactive oxygen species (ROS) or reactive nitrogen species (RNS), coupled with a reduced concentration or diminished activity of antioxidants responsible for neutralizing these reactive species