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The mPTP plays dual roles in cell survival and death, depending on the duration and extent of opening: transient openings participate in the physiological regulation of calcium homeostasis, bioenergetics, and redox balance, whereas sustained opening leads to mitochondrial swelling, outer membrane rupture, and subsequent apoptotic and necrotic death, which are important in various diseases

Hematology 20 , 311312 (2015)

10.1128/IAI.01344-06 Infect

A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human acute promyelocytic leukemia HL-60 cells

[3] Fernndez-Lzaro, D., Domnguez-Ortega, C., Busto, N., Santamara-Pelez, M., Roche, E., Gutirez-Abejn, E., & Mielgo-Ayuso, J

This finding may explain alcohols widespread effects on neuronal activity and brain function