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According to Healthline , vitamin B12 injections are considered generally safe, but some do have allergic reactions or sensitivity

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Refrigerate your Lipo B immediately after reconstitution, verify the beyond-use date with your pharmacy, and discard any vial that's been temperature-compromised

-- ConsumerLab.com Tests Lipoic Acid Supplements for Quality, Identifying Top Picks White Plains, New York, December 6, 2016 Alpha-lipoic acid supplements may improve insulin sensitivity and blood sugar control in people with type 2 diabetes, reduce symptoms of diabetic peripheral neuropathy, and enhance weight loss when dieting

The FDAs concern is twofold: Safety: Some substances are linked to toxicity, cardiac complications, or other serious adverse events

This is by Vasireddi et al., so theres a bunch of different authors