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Under hyperglycemic conditions, inhibition of this pathway can cause mesangial cell apoptosis and fibrosis, thereby adversely affecting the kidneys

Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancer

Experimental results showed that metformin effectively lowered total testosterone levels and free androgen index ( Metformin exerts its efficacy by effectively reducing blood glucose levels, mitigating IR, and facilitating improvements in abnormal glucose metabolism markers

In: Davies D.D., editor

The highway runs faster from both interventions

Paclitaxel, a widely used chemotherapeutic agent, increases ATAD3A expression and thereby prevents PINK1-dependent mitophagy, which impairs the degradation of PD-L1 and contributes to therapy resistance