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One proposed hypothesis, as yet untested, is that high-dose folic acid supplements cause depletion of the transport protein holotranscobalamin in serum, thus exacerbating B12 deficiency

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In children with Crohns disease, 30 percent to 40 percent have inflammation in the stomach, duodenum, or both

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This has happened before, at least twice, and when it has it has represented periods in time where anti-doping and regulators were scrambling to catch up to illegal drugs or substances that had become mainstream
