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Moreover, emerging molecular data suggest that SUM in Asian populations often harbours KIT (KIT protooncogene, receptor tyrosine kinase) or GNAQ (guanine nucleotide-binding protein, alpha Q polypeptide) mutations rather than the classical BRAF/NRAS (v-raf murine sarcoma viral oncogene homolog B/ neuroblastoma RAS viral oncogene homolog) alterations seen in sun-exposed melanomas, underscoring its distinct pathogenesis and therapeutic implications

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In vivo, AA-2G undergoes enzymatic hydrolysis to slowly release ascorbic acid, achieving sustained antioxidant effects, with 1.8% AA-2G providing an antioxidant effect equivalent to that of 15% ascorbic acid

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doi: 10.1007/s13679-021-00426-0