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DHT is a male hormone that can accumulate in the prostate and stimulate its growth

DHODH activity is essential for proliferating cells owing to their increased demand for nucleotides, and DHODH inhibition has long been studied as a therapeutic strategy in autoimmune diseases (for example, via leflunomide) and cancer, where it can lead to cell cycle arrest, DNA damage and replication stress 42,44,45

For example, treatment outcomes may be influenced by the placebo effect, which can vary based on the expectation of outcomes from specific treatments, and some patients may experience spontaneous improvement

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The complete sequence of a human genome

All in vitro experiments were independently repeated three times