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S2(R1) recommends two options for such assessment

The mercapturates are generally more polar and water soluble than the original electrophiles and are readily excreted in the urine and/or bile

Kadir, M

Taymouri S, Minaiyan M, Ebrahimi F, Tavakoli N

The regulatory status of a substance may, however, change, and the interpretation of prohibited lists can be complex

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