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If they do form, the thread is extracted and re-implanted along a modified pathway

Although the pathophysiology of hypertension is extremely complex and multifactorial, and the role of factors such as endothelin, 2 cyclooxygenase-dependent vasoconstrictors 3 and endothelium-derived hyperpolarizing factor 4 needs to be acknowledged, numerous experimental animal studies suggest that this condition is associated with an increased formation of reactive oxygen species (ROS) from all layers of the vascular wall

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Causes: Allopurinol, phenytoin, isoniazid, quinine, penicillin, quinidine Vascular lesions: They result from injury to the vascular endothelium