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Sikiric P et al

Dysregulation of GHIGF-1 axis can amplify the synergistic effect of GH and IGF-1 to promote uncontrolled cell proliferation, cell movement, angiogenesis, and suppress apoptosis to increase risk of neoplasia (272)

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Short-term safety is well-established at doses up to 1200mg per day, but chronic daily supplementation may downregulate endogenous glutathione synthesis through negative feedback on gamma-glutamylcysteine synthetase