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The pain usually affects the lower extremities first and extends upward through hosiery-like sensory abnormalities [81, 82]
Signalling mechanisms and cellular functions of SUMO
2014;35:S518
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Yet, overproduction of reactive oxygen species (ROS), induced by environmental toxins, inflammation, or mitochondrial dysfunction, overwhelms the cellular antioxidant defense system, resulting in oxidative stress [27]
To facilitate synthesis of the extensive narrative data presented in Sections 6 and 7, a summary table is provided below, integrating the major psychological and physical adverse effects associated with non-medical testosterone and anabolicandrogenic steroid use across organ systems ( Table 2 )
