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According to recent animal research, the Th17 pathway plays a pivotal role in the pathogenesis of psoriasis
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10.1016/j.copbio.2014.06.010 7 ChenY.ZhangJ.CuiW.SilversteinR
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261 TNF--induced ROS oxidize the dynein light chain (LC8), enabling its binding to IB and promoting IB degradation by IKK, leading to NF-B activation
