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Aberrant regulation of histone modification like acetylation, methylation and phosphorylation levels on specific residues is implicated in a wide spectrum of cancers, including colorectal cancer

FASEB J Off Public Federation Am Soc Experimental Biol 33(3), 43764387

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For many patients, these interventions provide meaningful relief

Endoplasmic reticulum protein disulfide isomerase shapes T cell efficacy for adoptive cellular therapy of tumors

Variations in some of these may contribute directly or indirectly to increase an individuals risk of toxicity and may account for the wide inter-individual variability of paracetamol metabolism reported in some studies [17, 20, 27]
