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The other 16 studies were excluded because the animals were not rats ( n = 4), the studies involved cell culture and tissues ( n = 6), the studies did not assess antioxidant markers ( n = 5), and one text was not available in its entirety (Figure 2) [12,13,14,15,16,17,18,19,20,21]

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Cell Culture and Viability Assay Human hepatoblastoma (HepG2) cells were purchased from the Korea Cell Line Bank (Seoul, Republic of Korea)

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Manz DH, Blanchette NL, Paul BT, Torti FM, Torti SV

Consistent with these results, ZnT8 was significantly upregulated and showed clear co-localization with INS + GCG + cells, with higher ZnT8 intensity in INS + GCG + cells than in INS + GCG cells (Supplementary information, Fig