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Analyzing a series of studies using differing amounts of B12 via injection, the IOM determined that 1.5 g of absorbed B12 per day was enough to normalize red blood cell parameters (hematocrit, red blood cell volume, and anemia) in the average patient with pernicious anemia

Ilanne-Parikka P, Eriksson JG, Lindstrm J, Hmlinen H, Keinnen-Kiukaanniemi S, Laakso M, Louheranta A, Mannelin M, Rastas M, Salminen V, Aunola S, Sundvall J, Valle T, Lahtela J, Uusitupa M, Tuomilehto J