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however, it produces life-threatening complications such as pulmonary edema and edema all over the body that needs intubation and resuscitation

Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation

Each box: 15 pouches x 25ml

Thus, and for the sake of simplicity, it is frequently assumed that the ionization of the weak acids in the oil phase is negligible, Figure 8, from where the apparent (measured) partition coefficient, defined by Equation (11), can be derived for any phenolic antioxidant AH

In some embodiments, a formulation described herein further comprises from about 14 to about 17% of a gelling agent (e.g., poloxamer 407), and provides extended sustained release over a period of from about 1 week to about 3 weeks

Overall, these results indicate that chemically engineered protein drugs can provide novel bioactive analogs with enhanced stability, which is critical to produce advanced IL-2 analogs without affecting the biological activity, thus paving the way for the development of new protein therapeutics with potent activity